Fighting Aging as an Effective Altruism Cause: A Model of the Impact of the Clinical Trials of Simple Interventions
Abstract: The effective altruism movement aims to save lives in the most cost-effective ways. In the future, technology will allow radical life extension, and anyone who survives until that time will gain potentially indefinite life extension. Fighting aging now increases the number of people who will survive until radical life extension becomes possible. We suggest a simple model, where radical life extension is achieved in 2100, the human population is 10 billion, and life expectancy is increased by simple geroprotectors like metformin by three more years on average, so an additional 250 million people survive until “immortality”. The cost of clinical trials to prove that metformin is a real geroprotector is $60 million. In this simplified case, the price of a life saved is around 24 cents, 10 000 times cheaper than saving a life from malaria by providing bed nets. However, fighting aging should not be done in place of fighting existential risks, as they are complementary causes.
Highlights:
● Aging and death are the main causes of human suffering now.
● Simple interventions could extend human lives until aging is defeated.
● These interventions need to be clinically tested before FDA approval.
● A trial of the life extension drug metformin is delayed by lack of funds.
● Starting trials now will save 250 million people from death, at a cost of $0.24 for each life saved.
Please comment on the preprint of the article here: https://goo.gl/WaEYt5
Reading through this I have some pretty significant concerns.
First the model behind the "$0.24 for each life saved" figure seems very suspect:
I am also unconvinced by the quality of argument elsewhere in the paper. For instance in the section "False arguments against badness of death" they list common arguments against the badness of death and then claim to refute them. However the responses are often extremely shallow and do not engage at all with the core of the argument. Here are some examples:
The paper contains many other arguments of a similar level of quality, and so although I largely agree with many of its conclusions, I find it generally very uncompelling.
Finally, as the most minor point there are quite a high number of grammatical issues.
Thank you for review.
Taking median date of the AI arrival like 2062 is not informative as in half cases it will not be here at 2062. The date of 2100 is taken as the date when it (or other powerful life-extending technology) almost sure will appear as a very conservative estimate. Maybe it should be justified more in the text.
Yes, it is assumed by Barzilai and gwern that metformin will extend human life 1 year, based on many human cohorts studies, but to actually prove it we need TAME study, and until this study is finished, metformin can't be used as a li... (read more)